For enhanced safety, the front and rear seat shoulder belts of the Mercedes E-Class All-Terrain Wagon have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Nissan Murano doesn’t offer pretensioners for its rear seat belts.
The E-Class All-Terrain Wagon’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Murano doesn’t offer pre-crash pretensioners.
The E-Class All-Terrain Wagon has a standard Post Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Murano doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the E-Class All-Terrain Wagon. But it costs extra on the Murano.
When descending a steep, off-road slope, the E-Class All-Terrain Wagon’s standard Downhill Speed Regulation allows you to creep down safely. The Murano doesn’t offer Downhill Speed Regulation.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The E-Class All-Terrain Wagon has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The Murano doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
Both the E-Class All-Terrain Wagon and Murano have rear cross-traffic warning, but the E-Class All-Terrain Wagon has Active Brake Assist (automatically applies the brakes) to better prevent a collision when backing near traffic. The Murano’s Rear Cross Traffic Alert doesn’t automatically brake.
Both the E-Class All-Terrain Wagon and the Murano have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available lane departure warning systems.
The Mercedes E-Class All-Terrain Wagon weighs 410 to 683 pounds more than the Nissan Murano. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.

